The Las Vegas Raiders dominated the Los Angeles Chargers 63-21, leading to the firing of Chargers coach Brandon Staley and general manager Tom Telesco.
The Cincinnati Bengals kept their playoff hopes alive with an overtime victory over the Minnesota Vikings.
The Indianapolis Colts scored 30 unanswered points in a decisive win against the Pittsburgh Steelers.
The Detroit Lions secured a convincing 42-17 victory over the Denver Broncos on Saturday night.
The Tampa Bay Buccaneers strengthened their playoff chances with a win, while the Carolina Panthers secured their second victory of the season.
The Houston Texans won a divisional game in overtime without QB C.J. Stroud.
The Buffalo Bills showcased a historic rushing performance, defeating the Dallas Cowboys 31-10.
The San Francisco 49ers clinched the NFC West with a win over the Arizona Cardinals.
The Bills' passing defense excelled, pressuring Dak Prescott and limiting the Cowboys' passing game.
The Dallas Cowboys' loss raised questions about their vulnerability to teams with a strong running game.
Rookie quarterback Bryce Young led the Carolina Panthers to a narrow 9-7 victory over the Atlanta Falcons.
The Miami Dolphins blanked the New York Jets 30-0, with WR Jaylen Waddle stepping up in the absence of Tyreek Hill.